@import url('https://fonts.googleapis.com/css2?family=Sora:wght@300;400;500;600;700;800&family=Noto+Sans+JP:wght@300;400;500;600;700;900&display=swap');

:root {
  --char: #2C2C2C;
  --char-light: #444;
  --blue: #5B7FA4;
  --blue-pale: #EEF3F7;
  --terra: #C4734F;
  --terra-hover: #A85E3E;
  --white: #FFFFFF;
  --off: #FAFAFA;
  --g50: #F7F7F7;
  --g100: #F0F0F0;
  --g200: #E2E2E2;
  --g300: #CCCCCC;
  --g400: #999;
  --g500: #717171;
  --g600: #555;
  --text: #2C2C2C;
  --sub: #555;
  --mute: #999;
  --rule: #E2E2E2;
  --rule-thick: #2C2C2C;
  --hd: 'Sora', 'Noto Sans JP', sans-serif;
  --bd: 'Noto Sans JP', sans-serif;
  --mw: 960px;
  --hh: 60px;
}

*,*::before,*::after{margin:0;padding:0;box-sizing:border-box}
html{scroll-behavior:smooth;-webkit-text-size-adjust:100%}
body{font-family:var(--bd);font-weight:400;color:var(--text);background:var(--white);line-height:1.85;font-size:14px;-webkit-font-smoothing:antialiased;overflow-x:hidden}
img{max-width:100%;display:block}
a{text-decoration:none;color:inherit;transition:color .2s}
ul,ol{list-style:none}
table{border-collapse:collapse;width:100%}

.w{max-width:var(--mw);margin:0 auto;padding:0 24px}
.w-wide{max-width:1200px;margin:0 auto;padding:0 24px}

.lbl{font-family:var(--hd);font-size:10px;font-weight:600;letter-spacing:.25em;text-transform:uppercase;color:var(--blue);margin-bottom:8px}
.ttl{font-family:var(--bd);font-size:28px;font-weight:700;color:var(--char);line-height:1.35;margin-bottom:12px}
.dsc{font-size:14px;color:var(--sub);line-height:1.85;max-width:560px}
.hd-c{text-align:center;margin-bottom:48px}
.hd-c .dsc{margin:0 auto}

.ph{border:1.5px solid var(--g200);display:flex;align-items:center;justify-content:center;color:var(--g400);font-size:12px;font-weight:500;letter-spacing:.04em;background:var(--g50)}

/* Reveal */
.rv{opacity:0;transform:translateY(18px);transition:opacity .6s cubic-bezier(.22,1,.36,1),transform .6s cubic-bezier(.22,1,.36,1)}
.rv.vis{opacity:1;transform:none}

/* ===== HEADER: minimal bar, overlay nav ===== */
.hdr{position:fixed;top:0;left:0;right:0;height:var(--hh);background:var(--white);border-bottom:1px solid var(--rule);z-index:1000;transition:box-shadow .3s}
.hdr.scrolled{box-shadow:0 1px 12px rgba(0,0,0,.04)}
.hdr-in{max-width:var(--mw);margin:0 auto;padding:0 24px;height:100%;display:flex;align-items:center;justify-content:space-between}
.logo{display:flex;align-items:center;gap:8px}
.logo-m{font-family:var(--hd);font-size:18px;font-weight:800;color:var(--char);line-height:1}
.logo-t{font-size:12px;font-weight:600;color:var(--char)}
.logo-t small{display:block;font-size:9px;font-weight:400;color:var(--g500)}

.menu-btn{background:none;border:none;cursor:pointer;display:flex;flex-direction:column;gap:5px;width:24px;padding:0}
.menu-btn span{display:block;width:100%;height:1.5px;background:var(--char);transition:transform .3s,opacity .3s}
.menu-btn.open span:nth-child(1){transform:translateY(6.5px) rotate(45deg)}
.menu-btn.open span:nth-child(2){opacity:0}
.menu-btn.open span:nth-child(3){transform:translateY(-6.5px) rotate(-45deg)}

/* Full-screen overlay nav */
.nav-ov{
  position:fixed;inset:0;background:var(--white);z-index:999;
  display:flex;flex-direction:column;align-items:center;justify-content:center;gap:0;
  opacity:0;pointer-events:none;transition:opacity .35s;
}
.nav-ov.open{opacity:1;pointer-events:auto}
.nav-ov a{
  display:block;font-size:20px;font-weight:500;color:var(--char);
  padding:18px 0;border-bottom:1px solid var(--rule);width:280px;text-align:center;
  transition:color .2s;
}
.nav-ov a:first-child{border-top:1px solid var(--rule)}
.nav-ov a:hover{color:var(--blue)}
.nav-ov .ov-cta{
  margin-top:28px;width:280px;text-align:center;
  background:transparent;color:var(--terra);font-size:16px;font-weight:600;
  padding:14px;border:2px solid var(--terra);border-radius:6px;
}
.nav-ov .ov-cta:hover{background:var(--terra);color:var(--white)}

/* ===== HERO: full-width centered ===== */
.hero{padding:calc(var(--hh) + 64px) 0 0;text-align:center}
.hero .lbl{margin-bottom:16px}
.hero-tags{display:flex;gap:8px;justify-content:center;flex-wrap:wrap;margin-bottom:20px}
.hero-tag{font-size:11px;font-weight:600;color:var(--blue);border:1.5px solid var(--blue);padding:4px 12px;border-radius:3px;letter-spacing:.02em}
.hero h1{font-size:36px;font-weight:900;color:var(--char);line-height:1.35;margin-bottom:14px}
.hero h1 em{font-style:normal;border-bottom:3px solid var(--blue);padding-bottom:2px}
.hero-sub{font-size:14px;color:var(--sub);margin:0 auto 28px;max-width:520px;line-height:1.85}
.hero .btn{margin-bottom:10px}
.hero-note{font-size:10px;color:var(--mute);margin-bottom:40px}

/* Stats strip */
.hero-strip{
  border-top:2px solid var(--rule-thick);border-bottom:1px solid var(--rule);
  display:flex;justify-content:center;gap:0;
}
.hero-stat{padding:20px 48px;border-right:1px solid var(--rule);text-align:center}
.hero-stat:last-child{border-right:none}
.hero-stat-v{font-family:var(--hd);font-size:28px;font-weight:700;color:var(--char);line-height:1.1}
.hero-stat-v small{font-size:13px;font-weight:500}
.hero-stat-l{font-size:11px;color:var(--g500);margin-top:2px}

/* Photo banner */
.hero-banner{margin-top:48px}
.hero-banner .ph{width:100%;height:320px;border-radius:0}

/* ===== CTA BUTTON ===== */
.btn{
  display:inline-flex;align-items:center;justify-content:center;gap:8px;
  background:transparent;color:var(--terra);font-family:var(--bd);
  font-size:15px;font-weight:700;padding:14px 32px;border-radius:5px;
  border:2px solid var(--terra);cursor:pointer;
  transition:background .2s,color .2s,transform .15s;
}
.btn:hover{background:var(--terra);color:var(--white);transform:translateY(-1px)}

/* ===== FLOATING CTA ===== */
.fl-cta{position:fixed;bottom:20px;right:24px;z-index:900;opacity:0;transform:translateY(12px);pointer-events:none;transition:opacity .35s,transform .35s}
.fl-cta.vis{opacity:1;transform:none;pointer-events:auto}
.fl-cta .btn{font-size:13px;padding:12px 24px;background:var(--white);box-shadow:0 3px 20px rgba(0,0,0,.08);border-radius:28px}

/* ===== SUBJECTS: vertical rows ===== */
.subj{padding:80px 0}
.subj-list{border-top:2px solid var(--rule-thick)}
.subj-row{
  display:flex;align-items:center;gap:24px;padding:28px 0;
  border-bottom:1px solid var(--rule);transition:background .15s;
}
.subj-row:hover{background:var(--g50)}
.subj-row h3{font-size:17px;font-weight:700;color:var(--char);min-width:180px;flex-shrink:0}
.subj-row p{font-size:13px;color:var(--sub);line-height:1.7;flex:1}
.subj-row .s-link{font-size:13px;font-weight:600;color:var(--blue);flex-shrink:0;white-space:nowrap;display:flex;align-items:center;gap:4px;transition:gap .2s}
.subj-row:hover .s-link{gap:8px}

/* ===== REASONS: 2-col large ===== */
.reasons{padding:80px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.rsn-list{border-top:2px solid var(--rule-thick)}
.rsn-item{display:flex;align-items:flex-start;gap:40px;padding:36px 0;border-bottom:1px solid var(--rule)}
.rsn-left{min-width:240px;flex-shrink:0}
.rsn-n{font-family:var(--hd);font-size:48px;font-weight:800;color:var(--char);line-height:1;opacity:.12}
.rsn-left h3{font-size:17px;font-weight:700;color:var(--char);margin-top:4px;line-height:1.4}
.rsn-item p{font-size:13px;color:var(--sub);line-height:1.85;padding-top:4px}

/* ===== FLOW: vertical timeline ===== */
.flow-sec{padding:80px 0}
.timeline{position:relative;padding-left:40px;max-width:640px;margin:0 auto}
.timeline::before{content:'';position:absolute;left:15px;top:0;bottom:0;width:1.5px;background:var(--rule)}
.tl-step{position:relative;padding:0 0 48px 32px}
.tl-step:last-child{padding-bottom:0}
.tl-dot{
  position:absolute;left:-25px;top:2px;width:32px;height:32px;
  border:2px solid var(--blue);border-radius:50%;background:var(--white);
  display:flex;align-items:center;justify-content:center;
  font-family:var(--hd);font-size:13px;font-weight:700;color:var(--blue);z-index:1;
}
.tl-step h3{font-size:16px;font-weight:700;color:var(--char);margin-bottom:2px}
.tl-time{font-size:11px;font-weight:600;color:var(--blue);margin-bottom:6px}
.tl-step p{font-size:13px;color:var(--sub);line-height:1.7}

/* ===== VOICE: stacked full-width ===== */
.voice{padding:80px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.voice-list{border-top:2px solid var(--rule-thick)}
.v-item{padding:36px 0;border-bottom:1px solid var(--rule);display:flex;gap:24px;align-items:flex-start}
.v-av{width:48px;height:48px;border-radius:50%;flex-shrink:0;font-size:9px}
.v-body{flex:1}
.v-meta{display:flex;align-items:baseline;gap:12px;margin-bottom:6px}
.v-meta h4{font-size:14px;font-weight:700;color:var(--char)}
.v-meta span{font-size:11px;color:var(--g500)}
.v-tag{font-size:10px;font-weight:600;color:var(--blue);border-bottom:1px solid var(--blue);padding-bottom:1px;display:inline-block;margin-bottom:8px}
.v-body>p{font-size:13px;color:var(--sub);line-height:1.85}

/* ===== FAQ: 2-column style ===== */
.faq-sec{padding:80px 0}
.faq-list{border-top:2px solid var(--rule-thick)}
.fq{border-bottom:1px solid var(--rule)}
.fq-q{
  width:100%;background:none;border:none;padding:20px 0;
  display:grid;grid-template-columns:28px 1fr 20px;gap:12px;align-items:flex-start;
  cursor:pointer;text-align:left;font-family:var(--bd);font-size:14px;font-weight:600;color:var(--char);line-height:1.6;
}
.fq-label{
  width:28px;height:28px;display:flex;align-items:center;justify-content:center;
  font-family:var(--hd);font-size:11px;font-weight:700;color:var(--blue);
  border:1.5px solid var(--blue);border-radius:3px;flex-shrink:0;
}
.fq-tog{width:20px;height:20px;position:relative;margin-top:4px}
.fq-tog::before,.fq-tog::after{content:'';position:absolute;top:50%;left:50%;background:var(--g400);transition:transform .3s}
.fq-tog::before{width:10px;height:1.5px;transform:translate(-50%,-50%)}
.fq-tog::after{width:1.5px;height:10px;transform:translate(-50%,-50%)}
.fq.open .fq-tog::after{transform:translate(-50%,-50%) rotate(90deg)}
.fq-a{max-height:0;overflow:hidden;transition:max-height .4s cubic-bezier(.22,1,.36,1)}
.fq-a-in{padding:0 0 20px 40px;font-size:13px;color:var(--sub);line-height:1.85}

/* ===== CTA BAND: split layout ===== */
.cta-band{padding:48px 0;background:var(--char)}
.cta-band-in{display:flex;align-items:center;justify-content:space-between;gap:24px}
.cta-band-txt h2{font-size:20px;font-weight:700;color:var(--white);margin-bottom:4px}
.cta-band-txt p{font-size:12px;color:rgba(255,255,255,.45)}
.cta-band .btn{border-color:var(--terra);color:var(--terra);white-space:nowrap}
.cta-band .btn:hover{background:var(--terra);color:var(--white)}

/* ===== FOOTER: 2-col + full map ===== */
.ftr{background:var(--char);color:var(--white);padding:48px 0 0}
.ftr-row{display:flex;justify-content:space-between;gap:40px;padding-bottom:40px;border-bottom:1px solid rgba(255,255,255,.08)}
.ftr-left{max-width:360px}
.ftr-left p{font-size:12px;color:rgba(255,255,255,.55);line-height:1.8;margin-top:14px}
.ftr-right{display:flex;gap:48px}
.ftr-right nav a{display:block;font-size:12px;color:rgba(255,255,255,.55);padding:3px 0;transition:color .2s}
.ftr-right nav a:hover{color:var(--white)}
.ftr-right .ftr-info p{font-size:12px;color:rgba(255,255,255,.55);line-height:1.8}
.ftr-map{margin-top:40px;padding-bottom:40px;border-bottom:1px solid rgba(255,255,255,.08)}
.ftr-map iframe{width:100%;height:200px;border:none;border-radius:4px}
.ftr-btm{padding:18px 0;display:flex;align-items:center;justify-content:space-between}
.ftr-btm p{font-size:10px;color:rgba(255,255,255,.3)}
.ftr-legal{font-size:9px;color:rgba(255,255,255,.35);line-height:1.8;padding:24px 0;border-top:1px solid rgba(255,255,255,.08);margin-top:16px}

/* ===== BREADCRUMB ===== */
.bc{padding:calc(var(--hh) + 14px) 0 0;font-size:11px;color:var(--g500)}
.bc a{color:var(--g500)}.bc a:hover{color:var(--char)}
.bc span{margin:0 6px;color:var(--g300)}

/* ===== SUB HERO: centered full-width ===== */
.sub-hero{padding:36px 0 0;text-align:center;border-bottom:1px solid var(--rule)}
.sub-hero .hero-tags{justify-content:center}
.sub-hero h1{font-size:30px;font-weight:900;color:var(--char);margin-bottom:10px;line-height:1.35}
.sub-hero h1 em{font-style:normal;border-bottom:3px solid var(--blue)}
.sub-hero-desc{font-size:13px;color:var(--sub);max-width:540px;margin:0 auto 24px;line-height:1.85}
.sub-hero-note{font-size:10px;color:var(--mute);margin-top:10px;margin-bottom:32px}
.sub-hero-banner{margin-top:32px}
.sub-hero-banner .ph{width:100%;height:240px}

/* ===== CONCERNS ===== */
.concerns{padding:72px 0}
.con-list{max-width:640px;margin:0 auto;border-top:1px solid var(--rule)}
.con{display:flex;align-items:flex-start;gap:12px;padding:16px 0;border-bottom:1px solid var(--rule)}
.con-chk{flex-shrink:0;width:20px;height:20px;border:1.5px solid var(--blue);border-radius:3px;display:flex;align-items:center;justify-content:center;margin-top:2px}
.con-chk svg{width:11px;height:11px;stroke:var(--blue);fill:none;stroke-width:2.5}
.con p{font-size:14px;color:var(--char);font-weight:500}

/* ===== ABOUT DISEASE ===== */
.about-d{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.about-d-in{display:grid;grid-template-columns:1fr 1fr;gap:40px;align-items:start}
.about-d-txt h3{font-size:19px;font-weight:700;color:var(--char);margin-bottom:12px}
.about-d-txt p{font-size:13px;color:var(--sub);line-height:1.9;margin-bottom:12px}

/* ===== PRICING: stacked rows ===== */
.pricing{padding:80px 0}
.pr-header{display:flex;align-items:flex-end;justify-content:space-between;margin-bottom:8px;padding-bottom:12px;border-bottom:2px solid var(--rule-thick)}
.pr-info{display:flex;gap:14px;font-size:12px;color:var(--sub)}
.pr-info strong{color:var(--blue);font-weight:700}
.pr-labels{display:grid;grid-template-columns:180px 1fr 160px 1fr;gap:16px;padding:10px 0;font-size:11px;font-weight:600;color:var(--g500);border-bottom:1px solid var(--rule)}
.pr-row{display:grid;grid-template-columns:180px 1fr 160px 1fr;gap:16px;padding:18px 0;border-bottom:1px solid var(--rule);align-items:center;transition:background .15s}
.pr-row:hover{background:var(--g50)}
.pr-name{font-weight:700;color:var(--char);font-size:14px}
.pr-drug{font-size:12px;color:var(--g500)}
.pr-price{font-family:var(--hd);font-size:20px;font-weight:700;color:var(--char)}
.pr-price small{font-size:11px;font-weight:500}
.pr-price-sub{font-size:10px;color:var(--g500)}
.pr-for{font-size:12px;color:var(--sub)}
.pr-note{font-size:10px;color:var(--mute);margin-top:12px;line-height:1.7}

/* ===== CASES: stacked rows ===== */
.cases{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.cases-list{border-top:2px solid var(--rule-thick)}
.case-row{display:flex;gap:24px;padding:28px 0;border-bottom:1px solid var(--rule);align-items:flex-start}
.case-imgs{display:flex;gap:8px;flex-shrink:0}
.case-img-w{position:relative;width:120px;height:120px}
.case-img-w img{width:100%;height:100%;object-fit:cover;border-radius:4px}
.case-img-w span{position:absolute;top:4px;left:4px;font-size:9px;font-weight:700;color:var(--white);background:rgba(44,44,44,.7);padding:2px 6px;border-radius:2px}
.case-info h4{font-size:14px;font-weight:700;color:var(--char);margin-bottom:4px}
.case-info p{font-size:11px;color:var(--g500);line-height:1.7}

/* ===== DRUG COMPARE ===== */
.drug-cmp{padding:72px 0}
.cmp-tbl{border:1px solid var(--rule)}
.cmp-tbl th,.cmp-tbl td{padding:12px 16px;text-align:center;font-size:12px;border:1px solid var(--rule)}
.cmp-tbl thead th{background:var(--char);color:var(--white);font-weight:600;font-size:11px}
.cmp-tbl thead th:first-child{background:var(--char-light)}
.cmp-tbl tbody th{background:var(--g50);font-weight:600;color:var(--char);text-align:left}
.cmp-tbl .hl{background:var(--blue-pale);font-weight:600;color:var(--char) !important}

/* ===== TRIAL: stacked ===== */
.trial{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.trial-list{border-top:2px solid var(--rule-thick)}
.trial-row{display:flex;gap:24px;padding:28px 0;border-bottom:1px solid var(--rule);align-items:flex-start}
.trial-row h3{font-size:15px;font-weight:700;color:var(--char);min-width:200px;flex-shrink:0}
.trial-body{flex:1}
.trial-body p{font-size:12px;color:var(--sub);line-height:1.7;margin-bottom:10px}
.trial-pr{font-family:var(--hd);font-size:22px;font-weight:700;color:var(--char)}
.trial-pr small{font-size:11px;font-weight:500}
.trial-drg{font-size:11px;color:var(--g500);margin-top:8px;padding-top:8px;border-top:1px solid var(--rule);line-height:1.6}

/* ===== GLP-1: stacked full-width ===== */
.glp{padding:72px 0}
.glp-list{border-top:2px solid var(--rule-thick)}
.glp-row{padding:32px 0;border-bottom:1px solid var(--rule)}
.glp-tag{display:inline-block;font-size:10px;font-weight:600;color:var(--blue);border:1px solid var(--blue);padding:3px 8px;border-radius:2px;margin-bottom:10px}
.glp-row h3{font-size:17px;font-weight:700;color:var(--char);margin-bottom:8px}
.glp-row>p{font-size:13px;color:var(--sub);line-height:1.85;margin-bottom:14px;max-width:640px}
.glp-dl{display:grid;grid-template-columns:180px 1fr;gap:4px 16px;font-size:12px}
.glp-dl dt{font-weight:700;color:var(--char)}
.glp-dl dd{color:var(--g600);padding-bottom:8px;border-bottom:1px solid var(--g100)}

/* ===== REASONS COMPACT (sub-pages) ===== */
.rsn-c{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}

/* ===== LEGAL ===== */
.legal{padding:36px 0;border-top:1px solid var(--rule)}
.legal h4{font-size:11px;font-weight:600;color:var(--g500);margin-bottom:8px}
.legal p{font-size:10px;color:var(--mute);line-height:1.8}

/* ===== RESPONSIVE ===== */
@media(max-width:768px){
  :root{--hh:52px}
  .ttl{font-size:22px}
  .hero h1{font-size:26px}
  .hero-strip{flex-wrap:wrap}
  .hero-stat{padding:14px 28px}
  .hero-banner .ph{height:200px}
  .sub-hero h1{font-size:24px}
  .sub-hero-banner .ph{height:160px}
  .subj-row{flex-direction:column;gap:8px;align-items:flex-start}
  .subj-row h3{min-width:auto}
  .rsn-item{flex-direction:column;gap:8px}
  .rsn-left{min-width:auto;display:flex;align-items:center;gap:12px}
  .rsn-n{font-size:32px}
  .timeline{padding-left:32px}
  .tl-dot{left:-17px;width:26px;height:26px;font-size:11px}
  .v-item{flex-direction:column;gap:12px}
  .cta-band-in{flex-direction:column;text-align:center}
  .cta-band .btn{width:100%}
  .ftr-row{flex-direction:column;gap:28px}
  .ftr-right{flex-direction:column;gap:20px}
  .ftr-btm{flex-direction:column;gap:4px;text-align:center}
  .about-d-in{grid-template-columns:1fr}
  .pr-labels,.pr-row{grid-template-columns:1fr;gap:4px}
  .pr-labels{display:none}
  .pr-row{display:flex;flex-direction:column;gap:4px}
  .case-row{flex-direction:column}
  .case-imgs{width:100%}
  .case-img-w{width:calc(50% - 4px);height:auto;aspect-ratio:1}
  .trial-row{flex-direction:column;gap:8px}
  .trial-row h3{min-width:auto}
  .glp-dl{grid-template-columns:1fr}
  .cmp-tbl{display:block;overflow-x:auto;-webkit-overflow-scrolling:touch}
  .fl-cta{bottom:0;right:0;left:0;padding:12px 16px;background:var(--white);border-top:1px solid var(--rule)}
  .fl-cta .btn{width:100%;justify-content:center;border-radius:5px;box-shadow:none}
}